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Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives
Zhen Wang1,2, Hanwen Hu1, Yunjia Bao3
1Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, P.R. China.
Abstract:
Sex differences play a crucial role in determining tumor incidence, treatment sensitivity, and prognosis among men and women. However, current clinical cancer treatment strategies fail to account for these differences. Furthermore, the underlying mechanisms of tumor disparities between sexes remain elusive. Sex differences in sex chromosomes, hormone levels, metabolism, and immunity synergistically contribute to tumor-related disparities. As the demand for precision medicine escalates, there is an urgent need to conduct further exploration and research to address the tumor differences between sexes. In this review, we discuss the impact of biological sex differences on tumor cells and the tumor microenvironment, aiming to identify more effective strategies for tumor prevention and treatment.
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