Related Experiment Video
Updated: Feb 5, 2026
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
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Omics-based approaches for acute brain injury research
Jordan D Bird1,2, Mark S Cembrowski1,2,3, Mypinder S Sekhon1,2,4
1Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine.
Current Opinion in Critical Care
|February 3, 2026
Summary
Omics-based approaches, including genomics and proteomics, offer new ways to understand acute brain injury (ABI) and develop personalized treatments. These strategies can identify disease mechanisms and biomarkers for better patient management.
Area of Science:
- Neuroscience
- Genomics
- Proteomics
- Metabolomics
Background:
- Acute brain injury (ABI) presents diverse injury types and diseases.
- Current treatments for ABI are largely supportive, with limited disease-modifying therapies.
- Advances in patient outcomes for ABI have plateaued.
Purpose of the Study:
- To review the role and clinical implications of omics-based approaches.
- To advance acute brain injury (ABI) research through novel strategies.
- To explore how omics can improve ABI phenotyping and management.
Main Methods:
- Review of omics-based strategies (genomics, transcriptomics, proteomics, metabolomics).
- Analysis of their potential for disease mechanism insights and biomarker discovery.
- Examination of current limitations in ABI phenotyping and management.
Main Results:
- Omics strategies provide opportunities to identify key cellular pathways in ABI pathophysiology.
- These approaches can reveal diagnostic biomarkers for disease severity and treatment response.
- Current ABI care lacks nuanced phenotyping, which omics could provide.
Conclusions:
- Acute brain injury diseases require better methods for rapid phenotyping of injury severity and pathophysiology.
- Integrating multi-pronged omics-based strategies can achieve comprehensive phenotyping.
- This integrated approach holds promise for developing personalized management strategies in ABI.
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