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The Expression and Potential Role of MicroRNAs in Oral Lichen Planus

Mousa Ali Heba1,2, Resteu Anastasia3, Werner Andreas1

  • 1Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|February 4, 2026
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are implicated in oral lichen planus (OLP). This study identified differentially expressed miRNAs and their target genes, MYC and IL-24, suggesting a role in OLP pathogenesis and malignant transformation.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Oral lichen planus (OLP) is a chronic immune condition with unknown causes.
  • MicroRNAs (miRNAs) are regulators of gene expression and may play a role in T-cell mediated diseases like OLP.

Purpose of the Study:

  • To investigate the miRNA expression profile in OLP patients.
  • To identify potential target genes regulated by these miRNAs in OLP.

Main Methods:

  • Total RNA was extracted from OLP and control biopsies.
  • Differential miRNA expression was analyzed using NanoString technology and confirmed by RT-qPCR.
  • Target gene expression was investigated using RT-qPCR.

Main Results:

  • Eight miRNAs were upregulated and eight were downregulated in OLP tissues.
  • RT-qPCR confirmed upregulation of miR-155, miR-146a, miR-29a, miR-342 and downregulation of miR-205.
  • MYC and IL-24 gene expression negatively correlated with miR-29a and miR-205, respectively, suggesting regulatory roles.

Conclusions:

  • miRNAs are potentially involved in the immunopathogenesis of OLP.
  • miRNAs may also play a role in the malignant transformation of OLP.
Keywords:
malignant transformationmicroRNAsoral lichen planuspathogenesis

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