Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cooperative Allosteric Transitions

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...

Cooperative Allosteric Transitions

Cooperative Allosteric Transitions

Cooperative Allosteric Transitions

Cooperative Allosteric Transitions

Cooperative Binding of Transcription Regulators

Cooperative Binding of Transcription Regulators

Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome. Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...

Cooperative Binding of Transcription Regulators

Cooperative Binding of Transcription Regulators

Elements: Chemical Symbols and Isotopes

Elements: Chemical Symbols and Isotopes

A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Recent advances in the degradation of polytetrafluoroethylene (PTFE) at low temperature (≤100 °C).

Chemical science·2026

Same author

Accessing Medium-Sized Bridged Heterocycles via EnT-Catalyzed Intermolecular Dearomative (5 + 4) Cycloaddition of Furans and Oxazoles.

Journal of the American Chemical Society·2026

Same author

Cholesterol and Cholesterol-Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels.

Archiv der Pharmazie·2026

Same author

Step-Edge Functionalization by N-Heterocyclic Carbenes Enhances Catalytic Activity in Electrochemical CO<sub>2</sub> Reduction.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Early Amyloid Formation and Neuroinflammatory Response in a Bigenic Mouse Model Expressing Human α-Synuclein and Aβ.

Parkinson's disease·2026

Same author

Energy-Transfer Catalysis Enables the Birch-Type Reduction of 2-Pyridones.

Angewandte Chemie (International ed. in English)·2026

Same journal

Proton Transfer Shuttle Mediated Dormant-Active Balance for Accelerated and Controlled Polymerization of N-Carboxyanhydrides.

Angewandte Chemie (International ed. in English)·2026

Same journal

Chloride-Regulated Depolymerization of Aluminosilicate Networks for Fast Ion Transport Compliant Interfaces in Sustainable All-Solid-State Sodium Batteries.

Angewandte Chemie (International ed. in English)·2026

Same journal

Asymmetric Zn─N<sub>2</sub>O-Coordinated Hydrogen-Bonded Organic Frameworks for Electrochemical Hydrogen Peroxide Production and Wastewater Purification.

Angewandte Chemie (International ed. in English)·2026

Same journal

Photocatalytic Cascade Nitrogen Fixation for Selective Purification of Methane-Rich Coal-Bed Gas Over a Bimetallic MOF.

Angewandte Chemie (International ed. in English)·2026

Same journal

Scalable Art-Inspired Tessellated Covalent Organic Framework Membranes Enable Highly Selective Ion Separation.

Angewandte Chemie (International ed. in English)·2026

Same journal

Layered Copper-Anthraquinone Coordination Polymer Cathode Leveraging Dual-Redox Sites and Facilitated Ion Diffusion for High-Performance Lithium-Ion Batteries.

Angewandte Chemie (International ed. in English)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 5, 2026

Barnes Maze Testing Strategies with Small and Large Rodent Models

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

A General Group Testing Strategy for Discovering Chemical Cooperativity.

Philipp M Pflüger¹, Felix Katzenburg¹, Frederik Sandfort¹

¹Organisch-Chemisches Institut, Universität Münster, Münster, Germany.

Angewandte Chemie (International Ed. in English)

|February 4, 2026

Summary

This summary is machine-generated.

This study introduces a group-testing strategy to efficiently discover cooperative molecular interactions in complex chemical systems. This approach accelerates chemical discovery by reducing experiments needed to identify active pairs and new reagents.

Keywords:

combinatorial designs cooperativity group testing screening trifluoromethylthiolation

More Related Videos

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing

Published on: May 8, 2014

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Feb 5, 2026

Barnes Maze Testing Strategies with Small and Large Rodent Models

Barnes Maze Testing Strategies with Small and Large Rodent Models

Published on: February 26, 2014

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing

In vitro Cell Culture Model for Toxic Inhaled Chemical Testing

Published on: May 8, 2014

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Area of Science:

Chemistry
Chemical Biology
Materials Science

Background:

Multi-component chemical systems present a combinatorial challenge for experimental screening.
Discovering cooperative molecular interactions is crucial for advancing chemical synthesis and discovery.
Traditional screening methods are often inefficient for exploring vast chemical spaces.

Purpose of the Study:

To develop an efficient strategy for identifying cooperative molecular interactions within multi-component systems.
To accelerate the discovery of novel chemical reactivity and reagents.
To overcome the limitations of combinatorial explosion in chemical exploration.

Main Methods:

A statistics-based group-testing strategy was coupled with luminescence quenching assays.
Combinatorial design theory-based pooling and iterative deconvolution were employed.
Two algorithms, a greedy algorithm for group design and iterative sectioning for deconvolution, were implemented.

Main Results:

Screened 4,950 substrate pairs in only 504 experiments, identifying 15 cooperative pairs.
Identified active pairs demonstrated high reactivity with various reaction partners.
Discovered a bench-stable reagent for efficient and regioselective trifluoromethylthiolation.

Conclusions:

The developed group-testing framework significantly accelerates the discovery of cooperative reactivity.
This approach provides a broadly applicable method for optimizing experimental designs in chemical discovery.
The identified cooperative pairs and novel reagents open new avenues in synthetic chemistry.