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AACR Pediatric Cancer Progress Report 2025.
Kristin M Primm1, Elizabeth Blackman1, Brett M Sansbury1
1American Association for Cancer Research , Philadelphia, Pennsylvania.
Summary
The AACR Pediatric Cancer Progress Report details advances in treating childhood cancers, including targeted therapies and immunotherapies. It also highlights challenges like rare cancer treatment and access to care, urging more research and investment.
Area of Science:
- Oncology
- Pediatric Medicine
- Cancer Research
Background:
- The American Association for Cancer Research (AACR) released its first Pediatric Cancer Progress Report on December 4, 2025.
- This report reviews a decade of scientific and clinical progress in pediatric cancer.
- It addresses outcomes for children (0-14) and adolescents (15-19).
Purpose of the Study:
- To highlight scientific and clinical advances in pediatric cancer.
- To chronicle developments in molecularly targeted therapies, immunotherapies, and genomic profiling.
- To identify challenges and inequities in pediatric cancer care.
Main Methods:
- The report synthesizes a decade of research and clinical data.
- It analyzes progress in diagnosis, surveillance, and treatment of pediatric cancers.
- Key developments in targeted therapies and immunotherapies are chronicled.
Main Results:
- Significant advances have been made in treating pediatric cancers.
- Molecularly targeted therapies, immunotherapies, and genomic profiling are transforming care.
- Challenges persist, including lack of therapies for rare/aggressive cancers and access inequities.
Conclusions:
- Increased federal investment and international collaboration are crucial.
- Innovative research strategies are needed to accelerate progress.
- The report emphasizes the urgent need for continued efforts to improve pediatric cancer outcomes.
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