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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Reaction Rate02:53

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The rate of reaction is the change in the amount of a reactant or product per unit time. Reaction rates are therefore determined by measuring the time dependence of some property that can be related to reactant or product amounts. Rates of reactions that consume or produce gaseous substances, for example, are conveniently determined by measuring changes in volume or pressure.
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Reducing Line Loss01:18

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In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
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Measuring Reaction Rates03:09

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Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
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Tranexamic Acid Associated With Reduced Postoperative Transfusion Rates in Hip Fracture Surgery: A Retrospective

Ellen Geary1, Gerard A Sheridan2, Kealan Blake3

  • 1Orthopaedic Surgery, St. Vincent's University Hospital, Dublin, IRL.

Cureus
|February 4, 2026
PubMed
Summary
This summary is machine-generated.

Perioperative tranexamic acid (TXA) use in hip fracture surgery reduces the need for blood transfusions and improves postoperative hemoglobin levels. This study found no increased risk of venous thromboembolism (VTE) events with TXA administration.

Keywords:
hip fracturesafetythromboembolictranexamic acidtransfusion

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Area of Science:

  • Orthopedic Surgery
  • Trauma Surgery
  • Anesthesiology

Background:

  • Blood transfusions are common in hip fracture surgery and carry potential adverse effects.
  • Reducing allogeneic blood transfusions is a clinical priority.
  • Tranexamic acid (TXA) is an antifibrinolytic agent that may reduce perioperative blood loss.

Purpose of the Study:

  • To assess the impact of perioperative tranexamic acid (TXA) on transfusion rates and thromboembolic events in hip fracture patients.
  • To evaluate the effect of TXA on postoperative hemoglobin levels.

Main Methods:

  • Single-center, retrospective cohort study.
  • Inclusion of patients undergoing hip fracture surgery between August 1, 2019, and August 1, 2020.
  • Comparison of outcomes between patients who received TXA and those who did not.

Main Results:

  • TXA administration was significantly associated with reduced postoperative transfusion rates (RR 0.64, p = 0.022).
  • Postoperative hemoglobin levels were significantly higher in the TXA group (107 g/L vs 101 g/L, p = 0.0183).
  • No statistically significant increase in deep venous thrombosis (DVT) or pulmonary embolism (PE) was observed with TXA use (p = 0.242).

Conclusions:

  • Intraoperative TXA administration in hip fracture surgery reduces postoperative transfusion requirements and improves hemoglobin levels.
  • TXA does not appear to increase the risk of venous thromboembolism (VTE) in this patient population.
  • Further research is needed to optimize TXA dosage, delivery, and timing for hip fracture surgery.