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Updated: Feb 5, 2026
A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
Fc-mediated immune effector functions elicited by recombinant and live-attenuated herpes zoster vaccines
Zhuangzhuang Huang1, Pengfei Jin2, Hongxing Pan1,2
1School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, China.
Background:
The role of Fc-mediated immune responses in protecting against herpes zoster remains poorly understood. This study aimed to evaluate the Fc-mediated immune responses of anti-VZV glycoprotein E antibodies induced by two licensed varicella-zoster virus vaccines.
Research Design And Methods:
We established two cohorts, each consisting of 48 healthy participants aged 50 or above, who received either the ZVL or RZV. Serum samples were measured to evaluate the Fc-mediated immune responses for antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and antibody-dependent neutrophil phagocytosis (ADNP) against VZV-gE. The correlations between Fc-mediated functions and the IgG levels were also analyzed.
Results:
Both ZVL and RZV significantly induced Fc effector function responses against HZ in participants after vaccination. Compared with ZVL recipients, RZV recipients exhibited significantly higher increase-fold of ADCC responses (ZVL: 1.93-fold; RZV: 8.44-fold, p < 0.001). In each vaccine group, the younger recipients showed higher ADCC responses than did the older (ZVL: 2.17-fold vs. 1.45-fold, p = 0.0136; RZV: 8.93-fold vs. 7.43-fold, p = 0.0677). Similar patterns were observed for ADCP and ADNP responses.
Conclusion:
RZV induced superior Fc effector functions of VZV-gE antibodies compared to ZVL did. Older adults exhibited weaker Fc-mediated responses compared to younger adults following vaccination.
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