Related Experiment Video
Updated: Feb 6, 2026

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
Published on: July 25, 2025
Seeing Is Believing: IEC-HS after CAR T Cells
Joseph M Rocco1, Nirali N Shah2
1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Abstract:
Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) is a complication seen in patients receiving chimeric antigen receptor (CAR) T cells, more frequently in those with CD22- or BCMA-targeted constructs compared with CD19. While associated with higher CAR T-cell expansion and a unique cytokine profile, the constellation of three cytokines (IFNγ, IL10, and IL1RA) correlated most strongly with IEC-HS severity and may help guide preemptive interventions. See related article by Srinagesh et al., p. 225.
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