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Fenofibrate vs. Omega-3 in Pediatric Hypertriglyceridemia: A Randomized Controlled Trial.

Setila Dalili, Shahin Koohmanaee, Afagh Hassanzadeh Rad

    Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners
    |February 4, 2026
    PubMed
    Summary

    Fenofibrate effectively reduces triglyceride and cholesterol levels in children with hypertriglyceridemia compared to omega-3. This study suggests fenofibrate as a safe option for pediatric lipid management.

    Keywords:
    DyslipidemiasHyperlipidemiaHypertriglyceridemia

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    Area of Science:

    • Pediatric Endocrinology
    • Cardiovascular Health
    • Pharmacology

    Background:

    • Hypertriglyceridemia is increasingly prevalent in children.
    • Diet and exercise are often insufficient for managing pediatric hypertriglyceridemia.
    • Investigating effective treatments for pediatric hypertriglyceridemia is crucial.

    Purpose of the Study:

    • To compare the efficacy and safety of fenofibrate versus omega-3 fatty acids.
    • To evaluate lipid-lowering effects in pediatric patients with hypertriglyceridemia.

    Main Methods:

    • An open-label, randomized controlled trial involving 30 pediatric patients (8-18 years) with hypertriglyceridemia.
    • Participants received either fenofibrate (100 mg/day) or omega-3 (1,000 mg twice daily) for 12 weeks.
    • Triglyceride (TG), LDL-C, HDL-C, and total cholesterol levels were monitored.

    Main Results:

    • Fenofibrate significantly reduced triglyceride, LDL-C, and total cholesterol compared to omega-3.
    • Omega-3 supplementation showed a significant upward trend in HDL-C levels.
    • Intergroup differences in HDL-C changes were statistically significant.

    Conclusions:

    • Fenofibrate demonstrates safety and efficacy in lowering triglycerides in pediatric hypertriglyceridemia.
    • Further clinical research is recommended to confirm these findings.
    • Fenofibrate may be a valuable therapeutic option for pediatric lipid management.