Related Experiment Video
Updated: Feb 6, 2026
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Altered Salience-Default Mode Network Dynamics in Subclinical Depression: A Preclustering-Based Co-Activation Pattern
Bo Zhang1,2,3, Zhinan Yu1,2,3, Feifan Yan1,2,3
1Tianjin International Joint Research Center for Neural Engineering, Academy of Medical Engineering and Translational Medicine, Medical School, Tianjin University, Tianjin, China.
Background:
Neuroimaging studies frequently report aberrant spontaneous brain activity and functional connectivity within core functional networks, including the default mode network (DMN), frontoparietal network (FPN), and salience network (SN) in subclinical depression (SD). However, the dynamic coordination among these networks remains poorly understood, impeding comprehensive elucidation of the underlying neuropathology of SD.
Methods:
Resting-state functional magnetic resonance imaging (fMRI) data were collected from subjects with SD (n = 26) and healthy controls (HCs, n = 33). A preclustering-based co-activation pattern method was developed to investigate the dynamic patterns of network coordination. Finally, machine learning analysis was conducted to evaluate the potential of network dynamics for clinical diagnosis.
Results:
Subjects with SD exhibited decreased dwell time in the SN and increased transition frequency from the SN to DMN, which was positively correlated with depressive severity. Furthermore, an ensemble learning model based on SN-DMN dynamic features achieved a classification accuracy of 96.44% in distinguishing SD from HC.
Conclusion:
These findings underscore the potential of altered SN-DMN dynamics as candidates for future neuroimaging markers of SD and support a neurocognitive model whereby altered SN-DMN dynamic coordination makes subjects with SD more prone to internal directed attention biases, thereby contributing to self-related depressive symptoms like rumination.
More Related Videos
11:02Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
Published on: December 28, 2010
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
Related Concept Videos
01:05Long-term Depression
02:26Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
03:12Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
01:07What is a Mode?
There can be more than one mode in a data set if multiple values have the same highest frequency. For instance, suppose that the Statistics exam scores of 20 students are: 50; 53; 59; 59; 63; 63; 72; 72; 72; 72; 72; 76; 78; 81; 83; 84; 84; 84; 90; 93. Here, the mode is 72, as it occurs most frequently, five times.
A data set with two modes is called bimodal. For example,...
01:28Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
01:30Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...