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Updated: Feb 6, 2026

Modeling Myotonic Dystrophy 1 in C2C12 Myoblast Cells
Published on: July 29, 2016
Substance use may be associated with non-adherence to non-invasive ventilation in adults with myotonic dystrophy type
Jalal Moolji1, Erika MacIntyre1,2, Janice Richman-Eisenstat1
1Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Canada.
Abstract:
Adults with myotonic dystrophy type 1 who require non-invasive ventilation (NIV) often have difficulty with adherence. Few risk factors for non-adherence have been identified, and these are mostly unmodifiable. As part of a quality assurance initiative, we sought to identify psychosocial barriers to NIV adherence to improve supports around isolation and mental health. We found that substance use was associated with non-adherence to NIV in our cohort. Cognitive impairment, the receipt of provincial income support, presence of a psychiatric condition, living alone, and marital status were not associated with NIV adherence. Interventions that limit the impact of substance use may improve NIV in this population.
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