Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metallic Solids02:37

Metallic Solids

20.7K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.7K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Structures of Solids02:22

Structures of Solids

17.9K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.9K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.1K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K
Leveling Effect01:29

Leveling Effect

1.4K
In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
1.4K
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

779
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
779

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine learning-guided discovery of poly(ethylene terephthalate)-binding modules to enhance durable whole-cell degradation.

Bioresource technology·2026
Same author

Effects of Smoothened Agonist Exposure on Murine Craniofacial Development.

International dental journal·2026
Same author

MMP1 Modulates Head and Neck Squamous Cell Carcinoma Progression and Therapeutic Response Via Tumour Microenvironment.

International dental journal·2026
Same author

Severe Disc degeneration is associated with lower caudal subendplate hounsfield unit values in degenerative lumbar spinal stenosis.

BMC musculoskeletal disorders·2026
Same author

Contrasting 2001 and 2020 land cover states: Impacts on heterogeneous HONO chemistry and nitrate formation in China.

Journal of hazardous materials·2026
Same author

Effect of Intracapsular Pressure on Pulp Sensitivity in Teeth Affected by Jaw Cysts: A Clinical Study Combined With Finite Element Analysis.

International dental journal·2026

Related Experiment Video

Updated: Feb 6, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

14.1K

Tri-Layer Solid-State Nanopore Arrays with Crosstalk Suppression for High-Throughput, Femtomolar-Level Biosensing.

Silu Feng1,2, Qinglong Luo1,2, Siqi Ai1,3,4

  • 1State Key Laboratory of High-Performance Tools, Guangdong University of Technology, Guangzhou, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 4, 2026
PubMed
Summary

New solid-state nanopore arrays offer ultrasensitive, label-free biosensing. This innovation minimizes crosstalk and improves uniformity for advanced molecular detection and diagnostics.

Keywords:
Al2O3/Au/Si3N4 sandwich structurehigh‐throughput molecular detectionscalable nanofabricationsolid‐state nanopore arrays

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K
High-throughput Screening and Biosensing with Fluorescent C. elegans Strains
14:53

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains

Published on: May 19, 2011

18.5K

Related Experiment Videos

Last Updated: Feb 6, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

14.1K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K
High-throughput Screening and Biosensing with Fluorescent C. elegans Strains
14:53

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains

Published on: May 19, 2011

18.5K

Area of Science:

  • Nanotechnology
  • Biosensing
  • Materials Science

Background:

  • Solid-state nanopore arrays are promising for label-free biosensing.
  • Current limitations include inter-pore crosstalk and fabrication variability.
  • Overcoming these challenges is crucial for practical applications.

Purpose of the Study:

  • To develop a novel multilayer nanopore architecture for improved biosensing.
  • To address inter-pore crosstalk and fabrication uniformity issues.
  • To enable rational design and high-throughput deployment of nanopore biosensors.

Main Methods:

  • Fabrication of a multilayer Al2O3/Au/Si3N4 nanopore architecture using helium ion beam lithography.
  • Finite-element analysis to determine optimal inter-pore spacing for minimizing electric field coupling.
  • Design and fabrication of nanopore arrays with controlled pore size and spacing.

Main Results:

  • Identified critical inter-pore spacing (approx. 20x pore radius) to reduce crosstalk.
  • Achieved nanopore arrays with ~30 nm pores, <5% size variation, and 300 nm spacing for independent signal acquisition.
  • Demonstrated label-free detection of alpha-fetoprotein down to ~3 fM with a wide dynamic range.

Conclusions:

  • The developed multilayer nanopore architecture effectively minimizes crosstalk and enhances fabrication uniformity.
  • The platform enables statistically independent, parallel signal acquisition for high-throughput biosensing.
  • This work establishes a foundation for rational design and scalable deployment of advanced solid-state nanopore biosensors.