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This summary is machine-generated.

Despite challenges, many studies continue to cite flawed findings on thiopurine S-methyltransferase (TPMT) and cisplatin ototoxicity. This highlights the need for critical engagement with foundational literature and improved postpublication oversight.

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Area of Science:

  • Pharmacogenomics
  • Clinical Toxicology
  • Scientific Literature Analysis

Background:

  • The 2009 Nature Genetics article by Ross et al. linked TPMT to cisplatin-induced ototoxicity.
  • This foundational study's findings have faced significant challenges and criticisms over time.

Purpose of the Study:

  • To evaluate the continued citation of the 2009 Ross et al. article.
  • To assess how disputed findings regarding TPMT and cisplatin ototoxicity persist in scientific literature.

Main Methods:

  • A systematic review of 378 Google Scholar citations from 2009-2025.
  • Screening of 214 PubMed-indexed manuscripts to categorize citation nuance (positive, negative/mixed).
  • Independent review of citation context by two researchers, with discrepancies resolved by consensus.

Main Results:

  • The majority of citations presented the 2009 findings favorably or uncritically.
  • This pattern persisted even after the 2015 FDA cisplatin label revision acknowledging flaws.
  • A smaller proportion of citations acknowledged conflicting evidence or questioned the study's validity.

Conclusions:

  • Many authors continue to cite the 2009 study without acknowledging its limitations or challenges.
  • There is a need for enhanced postpublication oversight and more transparent editorial practices.
  • Authors must critically engage with foundational literature to ensure evidence-based clinical and research narratives.