Research progress on Rosa laevigata polysaccharides and perspectives on their potential mechanisms based on gut...

Area of Science:

• Biochemistry
• Pharmacology
• Microbiology

Background:

• Rosa laevigata polysaccharides (RLPs) are key bioactive compounds from Rosa laevigata.
• RLPs exhibit significant biological activities, including antioxidant, anti-inflammatory, antitumor, and immunomodulatory effects.
• Emerging research highlights their metabolic regulatory functions and prebiotic potential.

Purpose of the Study:

• To systematically review the extraction, isolation, purification, structural characterization, and biological activities of RLPs.
• To explore the prebiotic effects of RLPs on gut microbiota and microbial metabolites.
• To propose a pharmacological network for RLPs based on their systemic regulatory effects via SCFAs.

Main Methods:

• Systematic literature review of studies on RLPs.
• Analysis of research on RLP extraction, purification, and structural characterization.
• Evaluation of studies investigating RLP's impact on gut microbiota and SCFA production.

Main Results:

• RLPs possess diverse pharmacological activities and can be effectively extracted and characterized.
• RLPs act as prebiotics, restoring gut microbiota balance.
• RLP metabolism by gut microbes significantly increases short-chain fatty acids (SCFAs).

Conclusions:

• RLPs demonstrate broad bioactivities and significant prebiotic potential.
• Increased SCFAs from RLP gut metabolism may contribute to systemic physiological regulation.
• These findings provide a foundation for RLP pharmacological network construction and industrial development.