Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

130.1K
Overview
130.1K
Humoral Immune Responses01:36

Humoral Immune Responses

84.0K
Overview
84.0K
Active versus Passive Immunity01:31

Active versus Passive Immunity

10.8K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
10.8K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

17.6K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
17.6K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.9K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.9K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.1K
Overview
84.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Plato to Pareto: Defining the shape of infection's disease space.

Science advances·2026
Same author

Resilience integrates concepts in aging research.

iScience·2022
Same author

Multi-start Evolutionary Nonlinear OpTimizeR (MENOTR): A hybrid parameter optimization toolbox.

Biophysical chemistry·2021
Same author

Metabolomic Analysis of Diverse Mice Reveals Hepatic Arginase-1 as Source of Plasma Arginase in Plasmodium chabaudi Infection.

mBio·2021
Same author

Immunology's intolerance of disease tolerance.

Nature reviews. Immunology·2021
Same author

Uncovering drivers of dose-dependence and individual variation in malaria infection outcomes.

PLoS computational biology·2020
Same journal

AARS1 promotes tumor progression and immune evasion via ATF6 lactylation-mediated tryptophan metabolism in hepatocellular carcinoma.

Cell metabolism·2026
Same journal

Reactive species as regulators of immune cell metabolism, tolerance, and autoimmunity.

Cell metabolism·2026
Same journal

The interplay between the microbiome and immune cells in metabolic homeostasis and disease.

Cell metabolism·2026
Same journal

The metabolic basis of regulated cell death.

Cell metabolism·2026
Same journal

Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3.

Cell metabolism·2026
Same journal

Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.

Cell metabolism·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

8.4K

Peeing your immune troubles away.

David S Schneider1

  • 1Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.

Cell Metabolism
|February 4, 2026
PubMed
Summary
This summary is machine-generated.

Activating an immune response can harm the host. Troha et al. demonstrate that mice with systemic inflammation can mitigate cytokine damage by excreting them in urine.

More Related Videos

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

11.5K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.4K

Related Experiment Videos

Last Updated: Feb 6, 2026

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

8.4K
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

11.5K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

10.4K

Area of Science:

  • Immunology
  • Physiology

Background:

  • Immune responses, while crucial for fighting pathogens, can paradoxically harm the host.
  • Systemic inflammation involves widespread inflammatory responses that can lead to host damage.
  • Cytokines are key signaling molecules in immune responses but can be detrimental when circulating excessively.

Purpose of the Study:

  • To investigate a potential mechanism for mitigating self-inflicted harm during systemic inflammation.
  • To explore how the host manages circulating cytokines in inflammatory conditions.

Main Methods:

  • The study utilized a mouse model of systemic inflammation.
  • Researchers monitored cytokine levels and excretion pathways in the affected mice.

Main Results:

  • Mice experiencing systemic inflammation were found to excrete harmful circulating cytokines in their urine.
  • This urinary excretion represents a physiological mechanism to reduce the detrimental effects of excessive cytokines on the host.

Conclusions:

  • Urinary cytokine excretion is a significant host defense mechanism against self-inflicted damage during systemic inflammation.
  • Understanding this pathway could offer new therapeutic strategies for inflammatory diseases.