Related Experiment Video
Updated: Feb 6, 2026

Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
Published on: October 1, 2010
Ion channels of the human heart: A comprehensive four-chamber analysis
1Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States of America.
Abstract:
The human heart exhibits remarkable chamber-specific ion channel expression patterns that underlie the distinct electrophysiological properties of atrial versus ventricular myocardium. This comprehensive review examines the molecular architecture, biophysical properties, and functional roles of 79 ion channel subunits and related proteins across all four cardiac chambers based on quantitative transcriptomic data from non-diseased donor hearts. Understanding chamber-specific expression profiles is essential for comprehending cardiac electrophysiology, arrhythmia mechanisms, and the development of chamber-selective therapeutic strategies.
Related Concept Videos
Ion Channels
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
Chambers of the Heart
Deoxygenated blood from the body is received in the right...
Non-gated Ion Channels
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
Mechanically-gated Ion Channels
Ligand-gated Ion Channels
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
G-Protein Gated Ion Channels
Sensory...

