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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Triclosan's interference with endocrine signalling: A mechanistic investigation
Deepa Sharma1, Tarang Kumar Shah2, Reshma Sinha1
1Department of Animal Sciences, School of Life Sciences, Central University of Himachal Pradesh, Kangra 176206, India.
Abstract:
The triclosan (TCS) has been widely used as an antimicrobial and antibacterial agent in personal care products, medical, acrylic, veterinary, and household items. Owing to its capacity to interfere with hormone-regulated pathways, it has been evidenced as a potential endocrine-disrupting chemical. This review summarizes the existing data on the mechanistic basis of TCS-induced endocrine disruption, emphasizing its impacts on steroidogenesis, receptor-based signalling, thyroid hormone regulation, crosstalk with metabolic hormones, and transformation product hazards. Consolidating molecular and cellular studies, this review highlights TCS-altered major endocrine functions and identifies areas of concern requiring further investigation for risk assessment and regulatory decisions.
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