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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Triclosan's interference with endocrine signalling: A mechanistic investigation
Deepa Sharma1, Tarang Kumar Shah2, Reshma Sinha1
1Department of Animal Sciences, School of Life Sciences, Central University of Himachal Pradesh, Kangra 176206, India.
Toxicology Letters
|February 4, 2026
Summary
Triclosan (TCS), a common antimicrobial, acts as an endocrine-disrupting chemical. It interferes with hormone pathways, impacting steroidogenesis, thyroid regulation, and metabolic hormones, requiring further risk assessment.
Area of Science:
- Endocrinology
- Toxicology
- Environmental Health
Background:
- Triclosan (TCS) is a widely used antimicrobial agent in various consumer and medical products.
- Its potential to interfere with hormone pathways raises concerns about endocrine disruption.
Purpose of the Study:
- To review the mechanistic basis of TCS-induced endocrine disruption.
- To consolidate existing data on TCS's impact on major endocrine functions.
Main Methods:
- Literature review of molecular and cellular studies.
- Analysis of data on steroidogenesis, receptor signaling, thyroid hormone regulation, and metabolic hormone crosstalk.
Main Results:
- TCS interferes with steroidogenesis and thyroid hormone regulation.
- Evidence suggests TCS acts as an endocrine-disrupting chemical.
- Transformation products of TCS may also pose hazards.
Conclusions:
- TCS significantly alters major endocrine functions.
- Further research is needed for comprehensive risk assessment and regulatory decisions regarding TCS exposure.
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