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Updated: Feb 6, 2026

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
Published on: September 27, 2013
The expanding roles of adhesion GPCRs in neural circuit assembly
Shane Watson1, Richard C Sando1
1Department of Pharmacology, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240, USA.
Abstract:
Bidirectional trans-synaptic signaling directs synapse formation and neural circuit assembly. Increasing evidence supports that several subfamilies of adhesion G protein-coupled receptors (aGPCRs) control important mechanistic aspects of synapse assembly and neural circuit wiring by combining trans-synaptic adhesion with G protein-coupled receptor signaling. These subfamilies include Latrophilins (ADGRL), CELSRs (cadherin EGF LAG 7-transmembrane receptors/ADGRC), and BAIs (brain angiogenesis inhibitors/ADGRB). Recently, aGPCRs have been linked to neurological disorders, further emphasizing the important roles of these receptors for proper neurological functions. Here, we discuss our current understanding of the functions of several aGPCRs in synaptic circuits and their links to neurological and neurodevelopmental disorders.
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