Related Experiment Video
Updated: Feb 6, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Infectious mononucleosis with ampicillin rash and a positive rapid streptococcal antigen test: a case report
Shuhei Honda1, Tomoyuki Watanabe2
1Division of General Medicine, Health Co-op. Watari Hospital.
None:
Infectious mononucleosis (IM), caused by Epstein-Barr virus, often mimics group A streptococcal (GAS) pharyngitis and may result in an ampicillin rash when aminopenicillins are administered. We report a 22-year-old woman with fever, sore throat, lymphadenopathy, and a generalized erythematous rash after a 7-day course of amoxicillin-clavulanate. Although a rapid streptococcal antigen test was positive, non-tender lymphadenopathy and absence of left shift in the white blood cell count suggested viral infection, and the result was considered consistent with a carrier state rather than true GAS infection. No additional antibiotics were given ; corticosteroid and antihistamine treatment led to improvement. Serology confirmed acute Epstein-Barr virus infection, and throat culture revealed only alpha-hemolytic streptococci. This case underscores the diagnostic overlap between IM and streptococcal pharyngitis, the need for caution in interpreting rapid antigen tests, and the importance of avoiding unnecessary antibiotics in suspected viral illness.
Related Concept Videos
Data Reporting and Recording
Position-effect Variegation
Types of Reports I: Hands-off Report
Following are the key components and categories of hand-off reports:
Purpose and Process:
Position and Displacement
Serial Position Effect
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...

