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Pol Candela¹, Carme Figueredo¹, Felicia A Hanzu²

¹Endocrinology and Nutrition Department, Hospital Clinic Barcelona.

Vitamins and Hormones

|February 4, 2026

Abstract:

Mild autonomous cortisol co-secretion (MACS) in primary aldosteronism (PA)-referred to as Connshing syndrome, C-PA, or MACS-PA-has emerged as a clinically significant adrenal disorder that substantially influences the prognosis and management of PA. In this chapter, a comprehensive overview of current knowledge and recent advances in the pathophysiology, diagnosis, and clinical impact of Connshing syndrome is presented, highlighting its importance for personalized treatment strategies and improved patient outcomes.

Keywords:

Connshing Dexamethasone MACS Primary aldosteronism

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