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Published on: December 9, 2021
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Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma
Carli S Koster1,2,3, Chiara Lavitola1,2,3, Raluca Teodorescu1
1Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Summary
The nervous system and immune cells interact in asthma, influencing airway inflammation. This review explores how neural remodelling and neuroimmune crosstalk contribute to severe asthma, identifying potential drug targets.
Area of Science:
- Pulmonary Medicine
- Neuroscience
- Immunology
Background:
- The nervous system regulates lung functions like breathing and reflexes.
- Asthma involves airway hyperresponsiveness and inflammation, partly controlled by the nervous system.
- Neuroplasticity is increasingly recognized in severe asthma, indicating neural remodeling contributes to symptoms.
Purpose of the Study:
- To review the roles of airway neuroplasticity and neuroimmune interactions in type 2 inflammation in asthma.
- To explore the bidirectional communication between airway nerves and immune cells.
- To identify potential pharmacological targets by understanding neural remodeling and immune activation mechanisms.
Main Methods:
- Literature review focusing on neuroplasticity and neuroimmune interactions in asthma.
- Analysis of neuropeptides and cytokines in mediating nerve-immune crosstalk.
- Examination of mechanistic links between neural remodeling and immune responses.
Main Results:
- The nervous system plays a significant role in modulating airway inflammation and hyperresponsiveness in asthma.
- Bidirectional interactions between airway nerves and immune cells are crucial in asthma pathogenesis.
- Neuropeptides and cytokines are key mediators of this neuroimmune crosstalk.
Conclusions:
- Airway neuroplasticity and neuroimmune interactions are critical in the development of type 2 inflammation in asthma.
- Understanding these mechanisms can reveal novel therapeutic strategies for asthma management.
- Targeting neuropeptide and cytokine pathways may offer new avenues for pharmacological intervention in severe asthma.
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