Related Experiment Video
Updated: Feb 6, 2026
05:02
Mechanical Micronization of Lipoaspirates for Regenerative Therapy
Published on: March 15, 2019
8.2K
Cellular plasticity and regenerative mechanisms in the lung
Laure-Emmanuelle Zaragosi1,2, Isabelle Salwig3,2, Roxana-Maria Wasnick4,2
1Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and Centre National de la Recherche Scientifique, Valbonne, France.
Summary
The adult lung
Area of Science:
- Pulmonary Medicine
- Cell Biology
- Regenerative Medicine
Background:
- The adult lung faces constant environmental threats, requiring efficient regeneration.
- Epithelial stem and progenitor cells are crucial for lung repair.
- Cellular plasticity aids repair but can drive chronic lung diseases when altered.
Purpose of the Study:
- To review mechanisms of lung epithelial regeneration and plasticity.
- To explore how these processes contribute to lung repair and disease.
- To discuss therapeutic strategies targeting epithelial plasticity.
Main Methods:
- Integration of findings from animal models and human lung studies.
- Review of recent advances in single-cell and spatial transcriptomics.
- Analysis of cellular heterogeneity, progenitor states, and transitional intermediates.
Main Results:
- Identified key stem/progenitor cells: basal cells, alveolar type 2 cells, and others.
- Highlighted the dual role of cellular plasticity in repair and disease.
- Revealed insights into conserved and divergent mechanisms of cell fate decisions.
Conclusions:
- Lung regeneration depends on stem cell activity and cellular plasticity.
- Dysregulated plasticity and reduced regeneration contribute to chronic lung diseases like IPF and COPD.
- Targeting epithelial plasticity offers potential therapeutic avenues for lung diseases.
Related Concept Videos
00:58Plasticity
3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
01:31Plasticizers
372
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
372
01:21Plastic Behavior
580
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
580
01:14Plastic Deformations
455
It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
455
01:19Plastic Deformations
470
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
470
01:47Lung Capacity
56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K