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Updated: Feb 6, 2026

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Controlled Retrieval Relies on Directed Interactions between Semantic Control Regions and Visual Cortex: MEG Evidence

Susanne Eisenhauer1,2,3, Meichao Zhang4,5, Katya Krieger-Redwood6,2

  • 1Department of Psychology, University of York, YO10 5DD, United Kingdom susanne.eisenhauer@york.ac.uk.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 4, 2026
PubMed
Summary
This summary is machine-generated.

Semantic goals enhance brain activity in the semantic control network, facilitating faster information retrieval. The left inferior frontal gyrus (IFG) controls retrieval, while the posterior middle temporal gyrus (pMTG) integrates top-down and bottom-up processing.

Keywords:
MEGcontroleffective connectivityoscillationssemanticstop-down processing

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Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Semantic Cognition

Background:

  • Flexible retrieval of conceptual knowledge is crucial for goal-directed navigation and behavior.
  • The semantic control network, including left inferior frontal gyrus (IFG) and posterior middle temporal gyrus (pMTG), is implicated in orchestrating this flexible retrieval.
  • The precise interactions between semantic control regions and sensory input pathways remain incompletely understood.

Purpose of the Study:

  • To investigate the oscillatory dynamics and effective connectivity within the semantic control network during goal-directed semantic decisions.
  • To elucidate the roles of IFG and pMTG in integrating top-down control with bottom-up sensory information.
  • To understand how prior knowledge of task goals influences neural processing and information retrieval.

Main Methods:

  • Magnetoencephalography (MEG) was employed to record brain activity in human participants (both sexes).
  • Participants performed semantic decision tasks on word pairs under conditions with and without prior knowledge of the task goal.
  • Effective connectivity analyses were used to examine directed interactions between brain regions.

Main Results:

  • Prior task knowledge increased oscillatory activity in both IFG and pMTG.
  • IFG exhibited sustained feedback to pMTG when task goals were known, while feedback was delayed in the absence of goals.
  • Goal-dependent feedback from IFG coincided with earlier feedforward signaling from visual cortex to pMTG, enabling rapid retrieval.

Conclusions:

  • The pMTG acts as an integration hub, combining top-down control signals from IFG with bottom-up visual input to activate task-relevant semantic representations.
  • The IFG plays a crucial role in controlling goal-dependent semantic retrieval.
  • These findings reveal a spectro-temporal cascade of interactions supporting flexible cognitive adaptation to current goals.