Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Waves01:23

Brain Waves

4.1K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.1K
Gas Chromatography: Sample Injection Systems01:08

Gas Chromatography: Sample Injection Systems

1.6K
In gas chromatography, the sample is introduced as a vapor plug into the carrier gas stream for high efficiency and resolution. A microsyringe injects the sample solution into a heated sample port, vaporizing it and mixing it with the carrier gas. This process is important to ensure the sample is properly prepared for analysis. Thermally sensitive samples can be injected directly into the column and volatilized by slowly increasing the column temperature.
Two primary injection methods are used...
1.6K
Organization of the Brain01:30

Organization of the Brain

2.7K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.7K
Brain Imaging01:14

Brain Imaging

747
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
747
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection00:59

Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

425
In pharmacokinetics, the elimination rate of a drug following a capacity-limited model is primarily controlled by two parameters: Vmax and KM. These parameters are crucial in how the drug behaves inside the body after administration.
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
425
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

286
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
286

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.

Advanced healthcare materials·2026
Same author

Tissue-adhesive hydrogel optical fiber for peripheral optogenetic neuromodulation.

Nature communications·2026
Same author

Inverted metal-free active template synthesis of rotaxanes via axle‑mediated macrocyclization.

Nature chemistry·2026
Same author

Re-evaluation of bovine herpesvirus 4 genotyping based on the thymidine kinase gene.

Journal of virology·2026
Same author

Untethered thin-film neurostimulator wrapped around tiny nerve trunks for wireless neuromodulation.

Science advances·2026
Same author

The predictive value of combined assessment of estimated glucose disposal rate and non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for cardiovascular disease risk: a nationwide cohort study.

Frontiers in medicine·2026
Same journal

Kat5 deficiency in alveolar type II cells licenses STAT6-driven glycolytic reprogramming and pulmonary fibrosis.

Nature communications·2026
Same journal

Continuous nonthermal slab gap formed by progressive tearing beneath Northeast Asia.

Nature communications·2026
Same journal

Zeolitic isolated protonic acid sites-mediated NH<sub>3</sub> storage for robust NO<sub>x</sub> removal.

Nature communications·2026
Same journal

Coaxially nested component with asymmetric fiber resonant cavity and separation membrane for gaseous and dissolved gases detection.

Nature communications·2026
Same journal

Near-unity charge readout signal in a nonlinear resonator without matching the sensor dissipation.

Nature communications·2026
Same journal

Prokaryotic Schlafen proteins cleave tRNAs during type III CRISPR immunity.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

5.8K

Injectable hydrogel bioelectrostimulator for wireless deep brain neuromodulation.

Ming Yang1, Wenliang Liu1, Ping Chen1

  • 1National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

Nature Communications
|February 4, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed an injectable conductive hydrogel for wireless neuromodulation, offering a minimally invasive alternative to deep brain stimulation (DBS). This novel hydrogel bioelectronics shows promise for treating neurological disorders like Parkinson's disease.

More Related Videos

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice
08:38

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice

Published on: September 6, 2024

2.2K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K

Related Experiment Videos

Last Updated: Feb 6, 2026

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke
09:41

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

5.8K
Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice
08:38

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice

Published on: September 6, 2024

2.2K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Bioelectronics

Background:

  • Deep brain stimulation (DBS) is a key therapy for neurological and psychiatric disorders.
  • Current DBS methods face limitations including invasiveness, tethered configurations, and tissue compatibility issues.
  • There is a need for wireless, minimally invasive neuromodulation alternatives.

Purpose of the Study:

  • To develop an in situ-gelled injectable conductive hydrogel (ICH) for wireless neuromodulation.
  • To investigate the mechanism of electric-field localization for neuronal activation.
  • To evaluate the therapeutic efficacy of ICH-mediated stimulation in a Parkinson's disease rat model.

Main Methods:

  • In situ gelation of conductive hydrogel via bio-catalyzed polymerization and electrostatic self-assembly.
  • Wireless neuromodulation using high-frequency capacitive coupling.
  • Assessment of neuronal activation through calcium signaling and c-Fos expression.
  • Electrophysiological recordings to evaluate basal ganglia-cortical activity.
  • Behavioral testing and fMRI analysis in a Parkinson's disease rat model.

Main Results:

  • The injectable conductive hydrogel formed a stable, conductive, tissue-soft, and biocompatible network in vivo.
  • High-frequency capacitive coupling induced electric-field localization at the hydrogel-tissue interface, activating neurons.
  • ICH stimulation demonstrated enhanced calcium signaling, increased c-Fos expression, and balanced basal ganglia-cortical activity.
  • In Parkinson's disease rats, ICH stimulation improved locomotor behavior, preserved dopaminergic neurons, and restored functional connectivity and structural integrity.
  • fMRI confirmed restored functional connectivity and structural integrity post-ICH stimulation.

Conclusions:

  • The developed injectable conductive hydrogel enables wireless, minimally invasive neuromodulation.
  • This hydrogel bioelectronics platform offers a promising approach for treating neurological disorders.
  • The study highlights a novel strategy for localized electric field generation for neural activation.