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Updated: Feb 6, 2026

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
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Published on: February 9, 2014

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TFEB, FOXO3 and TLR4 in resveratrol-induced autophagy in a mucopolysaccharidosis IIIB mouse model

Estera Rintz1, Magdalena Podlacha2, Lidia Gaffke2

  • 1Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland. estera.rintz@ug.edu.pl.

Experimental & Molecular Medicine
|February 4, 2026
PubMed

Insights

Resveratrol may improve behavior and reduce inflammation in Mucopolysaccharidosis (MPS) type IIIB mice by modulating autophagy and immune responses. This study highlights resveratrol

Area of Science:

  • Neuroscience
  • Biochemistry
  • Immunology

Background:

  • Mucopolysaccharidosis (MPS) type IIIB is a neurodegenerative disorder.
  • Autophagy and immune responses are implicated in MPS IIIB pathogenesis.
  • Resveratrol shows potential anti-inflammatory and neuroprotective properties.

Purpose of the Study:

  • To investigate the correlation between autophagy and immune response in MPS IIIB mice.
  • To assess the effects of resveratrol on behavior and inflammation in MPS IIIB mice.
  • To identify molecular pathways involved in resveratrol's therapeutic effects.

Main Methods:

  • Behavioral tests were conducted on male and female MPS IIIB mice treated with resveratrol.
  • Molecular and biochemical analyses assessed autophagy markers and cytokine levels.
  • Correlation analysis was performed between behavioral changes and molecular markers.

Main Results:

  • MPS IIIB mice exhibit disturbed autophagy and immune responses.
  • Resveratrol treatment improved mouse behavior and modulated cytokine levels.
  • A correlation was observed between behavioral deficits, heparan sulfate, and TLR4 levels.
  • FOXO3 was identified as a key factor in resveratrol-induced autophagy.

Conclusions:

  • Resveratrol can modulate glycosaminoglycan degradation in MPS IIIB.
  • Resveratrol may reduce inflammation and normalize behavior in MPS IIIB mouse models.
  • Resveratrol's therapeutic effects involve FOXO3-mediated autophagy and immune modulation.

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