Plant-Multi-Pathogen Relationships: An Emerging Focus

Pathogen-host interactions can involve cooperation or synergy, as well as competition and coexistence among different species. The host plant can also influence the competition among pathogens through defense mechanisms that target one or multiple pathogens, either in an active or passive manner. Nonetheless, typically, more virulent pathogens manage to bypass the host's defence strategies to establish infection. Research on plant-pathogen interactions primarily focuses on the model systems of a single host being infected by a single disease and model systems like Arabidopsis thaliana or Nicotiana benthamiana infected with pathogen have been generally used to identify genetic and molecular mechanism involved in plant immunity. However, in natural environments, microbes exist within complex communities, and plant infections often involve multiple genotypes, introducing complexities that the single host-single disease model cannot adequately clarify. In this discussion, we explore the latest insights into the interactions between hosts and multiple pathogens, as well as their impacts on both host resistance and vulnerability. We emphasize recent developments in co-infection systems and examine their potential implications for the epidemiology and management of plant diseases.