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Atlas-Based Mapping of Traditional Chinese Medicine Effects on Tumor Microcirculation Regulation
I Ho1,2, Yijie Xie1,2, Zhipeng Liu1,2
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Immunity, Inflammation and Disease
|February 5, 2026
Summary
Traditional Chinese Medicine (TCM) effectively regulates tumor microcirculation by targeting angiogenesis and immune responses. Further research will integrate TCM into cancer therapy.
Area of Science:
- Oncology
- Pharmacology
- Immunology
Background:
- Tumor microcirculation is crucial for cancer progression, causing hypoxia, treatment resistance, and immune evasion.
- Traditional Chinese Medicine (TCM) offers multi-targeted, systemic regulation of the tumor microenvironment.
Purpose of the Study:
- To analyze bibliometric data and knowledge maps of TCM's role in regulating tumor microcirculation.
- To identify key factors, mechanisms, and research trends in TCM-based tumor microcirculation modulation.
Main Methods:
- Bibliometric and knowledge-map analysis of 300 publications (2003-2025) using CiteSpace and VOSviewer.
- Identification of key TCM formulations, constituents, and non-pharmacological interventions.
Main Results:
- TCM, including specific decoctions and compounds, modulates angiogenesis and immune cell infiltration via pathways like VEGF, PI3K/AKT, and HIF-1α.
- Acupuncture and related therapies normalize vascular structure, glycolytic activity, and immune polarization.
- Network pharmacology and molecular docking are advancing the understanding of TCM mechanisms.
Conclusions:
- TCM demonstrates significant potential for multidimensional regulation of tumor microcirculation.
- Future research should prioritize experimental validation and systems-level modeling for clinical translation.
- Integrating TCM into cancer therapy requires further investigation and validation.
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