Associations of Inflammatory Markers and Coronary Heart Disease in Different Gender Groups in Cohort NHANES 2003-2018
Related Experiment Video
Updated: Feb 6, 2026
Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
Published on: February 18, 2020
Anmin Ren1,2,3, Qianjun Liu1,2,3, Qian Gan1,2,3
1Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China, fudan.edu.cn.
Insights
This study found specific inflammatory markers predict coronary heart disease (CHD) differently in men and women. Lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) are key indicators for males, while LMR and neutrophil-to-lymphocyte ratio (NLR) are important for females.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Public Health
Background:
- Coronary heart disease (CHD) is a significant global health concern.
- Previous research indicates a link between inflammatory markers and CHD.
- The differential impact of these markers across sexes requires further investigation.
Purpose of the Study:
- To investigate the association between specific inflammatory markers and CHD in adult males and females.
- To identify sex-specific inflammatory markers predictive of CHD.
- To explore both linear and nonlinear relationships between markers and CHD.
Main Methods:
- Utilized data from 40,177 participants in the National Health and Nutrition Examination Survey (NHANES) 2003-2018.
- Analyzed four inflammatory markers: systemic immune-inflammation index (SII), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).
- Employed multivariate logistic regression, trend tests, and restricted cubic splines (RCSs) for correlation and relationship analyses, with gender stratification.
Main Results:
- In males, LMR, PLR, and SII showed a significant negative correlation with CHD, with nonlinear relationships observed for LMR, PLR, and SII.
- In females, LMR and NLR were identified as significant factors associated with CHD.
- PLR demonstrated a nonlinear relationship with CHD in females.
Conclusions:
- LMR, PLR, and SII are significant negative correlative markers for CHD in males.
- LMR and NLR are more accurate predictors of CHD in females.
- Inflammatory marker associations with CHD exhibit significant sex-specific differences.
Background:
Although previous studies have revealed the correlation between inflammatory markers and coronary heart disease (CHD), this study aims to explore the relationship between inflammatory markers and CHD in the male and female population, respectively.
Methods:
This study includes participants from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. Inflammatory markers included the following: systemic immune-inflammation index (SII), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). Multivariate logistic regression was performed to investigate the correlation between these inflammatory markers and CHD. The trend test was employed to examine potential linear trend associations, and the restricted cubic splines (RCSs) were utilized to depict nonlinear relationships.
Results:
The NHANES database including 40,177 participants was stratified into two cohorts: the CHD group (n = 1667) and the non-CHD group (n = 38,510). With further gender stratification, we found that LMR, PLR, and SII all exhibited negatively significant correlation with CHD in the male group, while LMR and NLR were meaningful factors in the female group. We also detected that LMR, PLR, and SII all have nonlinear relationship with CHD in the male group (p for nonlinear < 0.05), while PLR had nonlinear relationship with CHD in the female group (p for nonlinear < 0.05).
Conclusions:
Our study revealed that LMR, PLR, and SII are significantly negative correlative markers of CHD in males, while LMR and NLR are more accurate predictors of CHD in females.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease II: Pathophysiology
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:27Coronary Artery Disease V: Interprofessional Care