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Threshold Effect of C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index on Disease Activity in Rheumatoid Arthritis:
Lina Leng1, Quanyi Tang2, Ying Li3
1Department of Rheumatology, Xingtai People's Hospital, Xingtai, 054001, Hebei Province, China, xtrmyy.cn.
Mediators of Inflammation
|February 5, 2026
Summary
The CALLY index shows a significant nonlinear relationship with rheumatoid arthritis (RA) disease activity. This novel biomarker may help assess RA inflammation and severity, particularly at lower CALLY index levels.
Area of Science:
- Rheumatology
- Biomarker Discovery
- Inflammation Research
Background:
- Rheumatoid arthritis (RA) disease activity is typically assessed using disease activity scores (DAS28).
- The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index has not been previously evaluated in relation to RA disease activity.
Purpose of the Study:
- To investigate the relationship between the CALLY index and disease activity in RA patients.
- To explore both linear and nonlinear associations between the CALLY index and DAS28 scores.
Main Methods:
- A cohort of 1058 RA patients was analyzed.
- Multiple linear regression and two-stage segmented linear regression models were employed.
- The association between the CALLY index and DAS28-erythrocyte sedimentation rate (ESR) and DAS28-CRP scores was evaluated.
Main Results:
- A significant negative correlation was found between the CALLY index and both DAS28-ESR and DAS28-CRP.
- A dose-response relationship was observed, with a trend P < 0.001.
- Segmented regression revealed a significant nonlinear correlation, with the negative impact of CALLY on disease activity being more pronounced at lower levels.
Conclusions:
- The CALLY index demonstrates a significant nonlinear relationship with RA disease activity (DAS28).
- The CALLY index shows potential as a novel composite biomarker for reflecting RA inflammatory status and disease severity.
- The findings suggest the CALLY index may be particularly useful for assessing disease activity in patients with lower CALLY index values.
Keywords:
C-reactive protein-albumin-lymphocyte indexbiomarkerimmunityinflammationnutritionalrheumatoid arthritisMore Related Videos
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