Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

995
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
995
What is Behavior?00:54

What is Behavior?

10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
Second-Order Circuits01:17

Second-Order Circuits

3.6K
Integrating two fundamental energy storage elements in electrical circuits results in second-order circuits, encompassing RLC circuits and circuits with dual capacitors or inductors (RC and RL circuits). Second-order circuits are identified by second-order differential equations that link input and output signals.
Input signals typically originate from voltage or current sources, with the output often representing voltage across the capacitor and/or current through the inductor. For example, in...
3.6K
First-Order Circuits01:15

First-Order Circuits

3.8K
First-order electrical circuits, which comprise resistors and a single energy storage element - either a capacitor or an inductor, are fundamental to many electronic systems. These circuits are governed by a first-order differential equation that describes the relationship between input and output signals.
One common example of a first-order circuit is the RC (resistor-capacitor) circuit. These circuits are used in relaxation oscillators such as neon lamp oscillator circuits. When voltage is...
3.8K
The Y-to-Y Circuit01:19

The Y-to-Y Circuit

758
In a balanced four-wire wye-to-wye system, the arrangement involves wye-connected sinusoidal voltage sources and loads, connected through a neutral wire that links the neutral nodes of the source and load. The load impedance is connected across each phase of the load. The wye-connected source can be connected to the wye-connected load in four-wire and three-wire arrangements. A three-phase system is considered balanced when the load on each phase is equal, leading to uniform current flow and...
758
LC Circuits01:21

LC Circuits

3.3K
An LC circuit consists of an inductor and a capacitor, either in series or parallel. Consider a charged capacitor connected with an inductor in series. Before the switch is closed, all the energy of the circuit is stored in the electric field of the capacitor. When the switch is closed, the capacitor begins to discharge, producing a current in the circuit. The current, in turn, creates a magnetic field in the inductor. Because of the induced emf in the inductor, the current cannot change...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The human GABA <sub>A</sub> receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits.

microPublication biology·2026
Same author

Single-molecule nanophotonic resolution of binding dynamics from apo to fully liganded for a cyclic nucleotide-gated ion channel in cell-derived vesicles.

bioRxiv : the preprint server for biology·2026
Same author

The human GABA<sub>A</sub> receptor α4 subunit variant Ile114Asn linked to epilepsy impairs membrane expression with β3 and δ subunits.

bioRxiv : the preprint server for biology·2026
Same author

Enkephalin Gates D2-MSN Disinhibition of the Ventral Pallidum During Cocaine Abstinence.

bioRxiv : the preprint server for biology·2026
Same author

HCN channel currents underlie distinct neurophysiology of mediodorsal thalamus subnuclei.

bioRxiv : the preprint server for biology·2025
Same author

A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of <i>Scn1b</i>.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Related Experiment Video

Updated: Feb 6, 2026

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice
06:11

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

21.2K

Behavioral and Prefrontal Circuit Deficits in a Newly Developed Setbp1 Haploinsufficiency Mouse Model.

MacKenzie A Howard1, Mendee A Geist1, Gregory J Ordemann1

  • 1Department of Neurology, Dell Medical School University of Texas at Austin, Austin, Texas.

Biological Psychiatry Global Open Science
|February 5, 2026
PubMed
Summary

Mice with SETBP1-haploinsufficiency disorder (SETBP1-HD) exhibit ADHD and ASD-like behaviors. Cellular changes in the medial prefrontal cortex may explain the neurological disabilities in SETBP1-HD.

Keywords:
Attention-deficit/hyperactivity disorderAutism spectrum disorderBehaviorElectrophysiologyNeurodevelopmental disorder

More Related Videos

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
08:10

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Published on: November 24, 2015

20.8K
Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
11:05

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

5.8K

Related Experiment Videos

Last Updated: Feb 6, 2026

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice
06:11

Nest Building Behavior as an Early Indicator of Behavioral Deficits in Mice

Published on: October 19, 2019

21.2K
A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
08:10

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Published on: November 24, 2015

20.8K
Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model
11:05

Author Spotlight: A Battery of Highly Reproducible Behavioral Tests to Validate an Angelman Syndrome Murine Model

Published on: October 20, 2023

5.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • SET binding protein 1 (SETBP1) is crucial for cell cycle and gene transcription.
  • Loss-of-function variants in SETBP1 cause SETBP1-haploinsufficiency disorder (SETBP1-HD) and SETBP1-related disorders (SETBP1-RD).
  • SETBP1-HD is associated with ADHD, ASD, and intellectual disability.

Purpose of the Study:

  • To characterize behavioral, physiological, and cell morphology phenotypes in a novel mouse model of SETBP1-HD.
  • To investigate the neurological underpinnings of SETBP1-HD.

Main Methods:

  • Behavioral tests (open field, 3-chamber, Y-maze) assessed activity, social interest, and spatial learning.
  • Electrophysiology (whole-cell current clamp) measured neuronal excitability in the medial prefrontal cortex (mPFC).
  • Morphological reconstruction analyzed dendritic arborization in mPFC neurons.

Main Results:

  • SETBP1-haploinsufficient mice (Setbp1+/-) displayed hyperactivity, reduced social interest, and increased olfactory exploration.
  • Layer-5 extratelencephalic projection neurons in the mPFC showed hypoexcitability.
  • Apical dendritic arbors of prefrontal pyramidal neurons exhibited altered branch point and length distribution.

Conclusions:

  • Setbp1+/- mice present phenotypes mirroring ADHD and ASD observed in SETBP1-HD patients.
  • Identified cellular alterations in the mPFC may elucidate mechanisms underlying neuropsychiatric disabilities in SETBP1-HD.