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Competing Endogenous RNA Networks Reveal Long Non-coding RNAs as Potential Prognostic Biomarkers in Gastric Cancer: A
Sadra Salehi-Mazandarani1, Mohammad Hossein Donyavi2,3, Amirhossein Vedaei4
1Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced Biomedical Research
|February 5, 2026
Summary
This systematic review identifies long noncoding RNAs (lncRNAs) as prognostic biomarkers for gastric cancer (GC). The lncRNA CCDC144NL-AS1 shows significant prognostic value in GC patients, highlighting its potential clinical application.
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- Gastric cancer (GC) poses a significant global health burden.
- Competing endogenous RNA (ceRNA) networks involving long noncoding RNAs (lncRNAs) are increasingly recognized for their role in GC prognosis.
- A comprehensive systematic review and meta-analysis on lncRNAs as ceRNA in GC was lacking.
Purpose of the Study:
- To systematically review and meta-analyze studies investigating lncRNAs as competing endogenous RNA (ceRNA) biomarkers in gastric cancer (GC).
- To identify and evaluate the prognostic significance of lncRNAs in GC based on existing literature.
Main Methods:
- A systematic search of multiple databases (Web of Science, Embase, PubMed, Scopus, ProQuest, Google Scholar) was conducted up to September 20, 2024.
- Eligible studies reporting lncRNAs as prognostic biomarkers in GC were included.
- Meta-analysis was performed on highly reported lncRNAs to assess their prognostic values, including sensitivity analysis and publication bias evaluation.
Main Results:
- The review included 56 studies, evaluating 350 unique lncRNAs for their association with overall survival in GC patients.
- Twenty-eight studies were eligible for meta-analysis.
- Four lncRNAs (ADAMTS9-AS2, AL391152.1, CCDC144NL-AS1, and PVT1) were identified as the most frequently reported prognostic biomarkers. Meta-analysis confirmed the prognostic effect of CCDC144NL-AS1 (HR = 1.577, 95% CI: 1.382-1.801).
Conclusions:
- The lncRNA CCDC144NL-AS1, identified through ceRNA network studies, shows promise as a prognostic biomarker for gastric cancer.
- Further research is warranted to fully elucidate the functional roles of CCDC144NL-AS1 in the pathogenesis of GC.
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