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Pearly Penile Papules: A Systematic Review of Treatment Modalities
Daniel P Friedmann1, Isabella Martingano2, Nabeel Ahmad2
1Dr. Friedmann is with the Westlake Dermatology Clinical Research Center at Westlake Dermatology and Cosmetic Surgery in Austin, Texas.
The Journal of Clinical and Aesthetic Dermatology
|February 5, 2026
Summary
Pearly penile papules (PPP) are common, benign growths. Ablative lasers, liquid nitrogen, and other methods effectively treat PPP, leading to high patient satisfaction and minimal side effects.
Area of Science:
- Dermatology
- Cosmetic Surgery
Background:
- Pearly penile papules (PPP) are common, benign, and asymptomatic lesions.
- These papules can cause cosmetic concerns for patients.
Purpose of the Study:
- To systematically review all available treatment options for pearly penile papules (PPP).
Main Methods:
- Searched PubMed, Scopus, Embase, and Cochrane databases for studies on PPP treatment.
- Included 17 retrospective case reports/series involving 142 patients, excluding articles without treatment data or in non-English languages.
Main Results:
- Ablative lasers (CO2, Er:YAG, Ho:YAG) were the most common treatment (10 articles).
- Other modalities included liquid nitrogen, pulsed dye laser, fractional laser, and electrocoagulation.
- Most studies reported complete lesion removal, high patient satisfaction, and no infections or scarring.
Conclusions:
- Multiple treatment modalities offer safe and effective options for PPP.
- High patient and provider satisfaction is achievable with various treatments.
- Limitations include potential publication bias and variable reporting of efficacy and adverse events.
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