Primary Localized Supraglottic Amyloidosis Presenting With Hoarseness: A Case Report

Localized laryngeal amyloidosis is a rare condition, representing a small fraction of benign laryngeal lesions. Its clinical importance resides in its ability to mimic both benign and malignant tumors of the larynx, which often leads to a delayed diagnosis. The condition typically presents with hoarseness, although symptoms may range from mild vocal disturbances to significant airway compromise. Diagnosis requires histopathological confirmation with Congo red staining, as imaging and endoscopic findings alone are non-specific. Management is primarily surgical; functional preservation with endoscopic CO₂ laser excision is the preferred technique. Long-term monitoring and follow-up are required due to the frequent recurrence of the condition. We report a case of isolated laryngeal amyloidosis in a 34-year-old male patient presenting with persistent hoarseness, highlighting diagnostic challenges, therapeutic considerations, and the need for vigilant surveillance.