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Updated: Feb 6, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model.

Dominik L Maler1, Sabrina Reinehr1, Leonie Deppe1

  • 1Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany.

Frontiers in Cellular Neuroscience
|February 5, 2026
PubMed
Summary

Intermittent fasting protected against glaucoma-like damage in mice by reducing inflammation and preserving retinal ganglion cells (RGCs). This suggests fasting may be a potential therapy for glaucoma.

Keywords:
HSP27dietfastingglaucomaheat shock proteinsmacrogliaretinal ganglion cells

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Area of Science:

  • Ophthalmology
  • Immunology
  • Neuroscience

Background:

  • Glaucoma treatment is limited to lowering intraocular pressure due to poorly understood pathomechanisms.
  • Elevated antibodies against heat shock protein 27 (HSP27) are found in glaucoma patients.
  • Previous studies showed glaucoma-like damage in mice after intravitreal HSP27 injection.

Purpose of the Study:

  • To investigate the potential neuroprotective effects of intermittent fasting (IF) against HSP27-induced glaucoma-like damage in mice.
  • To explore the impact of IF on retinal ganglion cell survival and neuroinflammation in a mouse model of glaucoma.

Main Methods:

  • Mice received intravitreal injections of HSP27.
  • Animals were divided into two groups: ad libitum feeding and intermittent fasting (24h fast, 3 days/week).
  • Retinal ganglion cell counts, apoptosis markers, glial cell activation, and inflammatory cytokine expression (TNFα, IL-1β) were analyzed after 4 weeks.

Main Results:

  • HSP27 injection led to significant retinal ganglion cell loss and increased glial activation.
  • Intermittent fasting significantly preserved retinal ganglion cell numbers compared to controls.
  • Intermittent fasting downregulated pro-inflammatory markers (TNFα, IL-1β) in the retina and serum.

Conclusions:

  • Intermittent fasting demonstrates neuroprotective effects in a mouse model of glaucoma.
  • IF likely modulates neuroinflammatory pathways, thereby protecting retinal ganglion cells from damage.
  • Intermittent fasting may serve as a potential adjunctive therapeutic strategy for glaucoma management.