Related Experiment Video
Updated: Feb 6, 2026

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
Beyond death counts: how COVID-19 affected excess mortality and productive life-years lost across 28 European states,
Paweł Niewiadomski1, Jakub Wojtasik2, Błażej Łyszczarz3
1Doctoral School of Medical and Health Sciences, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
Introduction:
Excess mortality attributable to COVID-19 has been extensively investigated in the public health literature. This study extends the scope of previous findings by estimating three interrelated measures, excess deaths, excess Years of Life Lost, and excess Years of Potential Productive Life Lost, in 28 European countries across 2020-2023.
Materials And Methods:
Using annual sex- and 5-year age-specific mortality data for 2002-2019, we applied a multiverse modelling strategy combining all possible baseline windows with four alternative trend specifications. Expected mortality for 2020-2023 was obtained from the best-performing specification, derived using model selection criteria, after trimming outlying forecasts. We define excess mortality burden in terms of three measures: excess deaths, excess Years of Life Lost (eYLL), and excess Years of Potential Productive Life Lost (eYPPLL). Excess mortality was estimated by comparing observed and expected deaths, and was used to obtain eYLL and eYPPLL. Sensitivity analyses included alternative trend assumptions, time-series forecasts, and varying life-expectancy and labour market parameters.
Results:
We identified a total of 1,540,034 excess deaths, corresponding to 16,695,365 eYLL and 1,997,095 eYPPLL. Central and Eastern Europe bore the heaviest burden of excess deaths, while the Northern countries were the least affected by COVID-19 mortality. We identified a relatively high health burden in the working population, particularly among men and in Central and Eastern Europe. The male excess in productive life-years lost (eYPPLL) was the strongest among all three measures, further highlighting mortality burden in younger-aged men. These results underscore varying labour market vulnerability to the pandemic across European states.
Conclusion:
Our findings underscore marked geographic and sex differences in excess deaths and life-years lost, with particularly high disparities among the working-age population. These patterns emphasise the need for strengthening health systems' resilience and tailoring post-pandemic recovery efforts to the most affected populations.
Related Concept Videos
Half-life of a Reaction
Characteristics of Life
The Angiosperm Life Cycle
Excess Pressure Inside a Drop and a Bubble
The Tree of Life - Bacteria, Archaea, Eukaryotes
Functions of Life
Metabolism
The basic function of an organism is to consume energy and molecules in foods, convert some of it into fuel for movement, sustain body functions, and build and maintain body structures. There are two types of reactions that accomplish this: anabolism and catabolism.
Anabolism is the process whereby...

