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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Raspberry protective role in inflammatory diseases: An overview.

Priyanka Arya1, Vikram Sharma1, Priyanka Singh2

  • 1Galgotias College of Pharmacy, Greater Noida, U.P., India.

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|February 5, 2026
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Summary

Raspberries, rich in polyphenols, exhibit potent anti-inflammatory and antioxidant properties. They modulate key signaling pathways, offering therapeutic potential for inflammatory diseases like cardiovascular conditions, neurodegeneration, and cancer.

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Area of Science:

  • * Nutritional Science and Biochemistry
  • * Molecular Biology and Immunology
  • * Pharmacology and Therapeutics

Background:

  • * Inflammation is a fundamental immune response to pathogens, cellular damage, and toxins, potentially leading to acute and chronic inflammatory disorders.
  • * Inflammatory conditions encompass a range of diseases, including cardiovascular diseases, neuroinflammation, arthritis, and cancer.
  • * Immune cells and critical inflammatory signaling pathways are activated by both infectious and non-infectious stimuli.

Purpose of the Study:

  • * To review the mechanistic insights into the protective roles of raspberries (Rubus idaeus) in managing inflammatory-related disorders.
  • * To highlight the therapeutic potential of raspberry bioactive compounds against cardiovascular diseases, neurodegenerative conditions, and cancer.

Main Methods:

  • * Literature review focusing on studies investigating the anti-inflammatory and antioxidant properties of raspberry bioactive constituents.
  • * Analysis of research detailing the effects of raspberry compounds on various inflammatory signaling pathways (e.g., MAPKs, NF-κB, PI3K/Akt).
  • * Examination of studies reporting the pharmacological effects of raspberries, including cardioprotective, hepatoprotective, and anti-cancer activities.

Main Results:

  • * Raspberries are rich in polyphenols (anthocyanins, flavanols, phenolic acids, urolithin A, ellagic acid) with significant anti-inflammatory and antioxidant activities.
  • * These compounds effectively regulate multiple inflammatory signaling pathways, including MAPKs, NF-κB, PI3K/Akt, AP-1, IL-6, TNF-α, IL-1β, CD40, nitric oxide (NO), caspases, and the JAK-STAT pathway.
  • * Raspberry constituents demonstrate broad pharmacological benefits, such as anti-inflammatory, antioxidant, hepatoprotective, cardioprotective, gastroprotective, anti-obesity, skin depigmenting, and bone-regenerative properties.

Conclusions:

  • * Raspberries possess significant therapeutic potential for managing inflammatory disorders due to their rich bioactive compounds.
  • * The anti-inflammatory mechanisms involve the regulation of key signaling pathways, offering protective effects against cardiovascular diseases, neurodegenerative conditions, and cancer.
  • * Further research into raspberry's mechanistic actions can pave the way for novel therapeutic strategies against inflammation-related diseases.