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Updated: Feb 6, 2026

Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
Published on: November 18, 2011
Synthesis and antitumor activity of mono and digold(i) alkynyl complexes with oligo(ethylene glycol)methylether
Yanyan Zeng1,2, Fei Zheng3, Lingyu Jin1
1Department of Radiology, The Affiliated Hospital, Southwest Medical University NO.25, Taiping Road, Jiangyang District Luzhou 646000 Sichuan China xrenwenxiux@swmu.edu.cn.
Abstract:
Preparation and characterization of a series of oligo(ethylene glycol)methylether functionalized alkynyl gold(i) complexes capped with AuPPh3 (1a-1d) or dppfAu2 (dppf, 1,1'-bis(diphenyphosphino)ferrocene) (2a-2d) have been accomplished. The structures of 1b and 1c were established by X-ray crystallography. Their in vitro antitumor activities were measured by the CCK8 method against A549 and HeLa cells. The studies indicated that the cytotoxic activity in vitro was fine-tuned by modification of both the gold(i) centers and the oligo(ethylene glycol)methylether ancillary ligands. Compared to the dppfAu2 series, the AuPPh3 series showed better cytotoxicity. Especially, complex 4-(OCH2CH2OCH2CH2OCH3)C6H4C[triple bond, length as m-dash]CAuPPh3 (1d) displayed strong anticancer activity toward both cancer cells due to the strong inhibition of thioredoxin reductase (TrxR).
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