Related Experiment Video
Updated: Feb 6, 2026
05:52
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
13.3K
Comparative Study of Minimally Invasive with Open Surgical Staging Procedure for Endometrial Cancer: A
D Suresh Kumar1, S Navin Noushad1, Ajay Sharma1
1Tamil Nadu Government Multi Super Speciality Hospital, Chennai, Tamil Nadu India.
Indian Journal of Surgical Oncology
|February 5, 2026
Summary
Minimally invasive surgical staging for endometrial cancer offers better survival rates and less morbidity than open surgery. This approach results in reduced blood loss and shorter hospital stays, demonstrating oncological safety.
Area of Science:
- Gynecologic Oncology
- Surgical Oncology
- Minimally Invasive Surgery
Background:
- Endometrial cancer management involves surgical staging to determine extent and guide treatment.
- Traditional open surgical staging (laparotomy) is associated with significant morbidity.
- Minimally invasive surgical staging (laparoscopy/robotic) offers potential benefits but requires oncological validation.
Purpose of the Study:
- To compare oncological effectiveness, morbidity, and perioperative outcomes between minimally invasive and open surgical staging for endometrial cancer.
- To evaluate disease-free survival, operative time, blood loss, lymph node yield, and hospitalization duration.
- To assess the safety and efficacy of minimally invasive approaches in endometrial cancer management.
Main Methods:
- Retrospective analysis of 217 endometrial cancer patients treated between January 2015 and November 2024.
- Comparison of outcomes between open surgical staging (n=93) and minimally invasive surgical staging (n=124; 86 laparoscopic, 38 robotic).
- Statistical analysis using Fisher's exact test, Student's t-test, and Kaplan-Meier survival analysis (p≤0.05 significance).
Main Results:
- Minimally invasive surgery had shorter operative times (115 vs 136 min, p=0.009) and significantly less blood loss (60 vs 140 ml, p=0.007).
- Hospitalization was shorter for minimally invasive staging (4 vs 6 days, p=0.005), with no significant difference in lymph node retrieval (p=0.09).
- Disease-free survival at 3 years was higher in the minimally invasive group (95.2% vs 88.3%, p=0.003).
Conclusions:
- Minimally invasive surgical staging is oncologically safe and effective for endometrial cancer.
- It offers superior perioperative outcomes, including reduced blood loss and shorter hospital stays.
- This approach is associated with improved disease-free survival compared to open surgical staging.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
419
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
419
02:07Blind Procedures
13.5K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
13.5K
02:43Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
01:12What is an Experiment?
18.8K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.8K
02:21Cancers Originate from Somatic Mutations in a Single Cell
14.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.9K
01:11Bioavailability Study Design: Single Versus Multiple Dose Studies
246
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
246