Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis
Wenxuan Xue1, Jing Jia1, Mingtao Wu1
1Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.
Abstract:
Precise control of chemo- and regioselectivity in intermolecular difunctionalization of alkenes remains a long-standing challenge in organic synthesis. Here, we report a heterogeneous cobalt single-atom-site catalyst that enables selective 1,2-sulfonamidoazidation of styrenes. The system features good functional group tolerance and excellent recyclability. By leveraging the characteristics of single-atom-site catalysis, this work provides a valuable platform for achieving highly selective, efficient, and sustainable styrene functionalization.
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