Preparation of α-Chloroketones via Oxo/Chloro Difunctionalization of Unactivated Alkenes under Mild Conditions
Xuheng Zhu1, Chaolin Li2, Xianjin Yang1
1Key Lab for Advanced Material and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China.
Abstract:
A one-step synthesis of α-chloroketones via transition metal-free-mediated oxo/chloro difunctionalization of unactivated alkenes using N-chloro-N-fluorobenzenesulfonamide (CFBSA) is reported, and both aromatic and aliphatic alkenes can be efficiently converted into their corresponding α-chloroketones by simply choosing different conditions. This reaction system has several characteristics such as a wide substrate scope, excellent functional group tolerance, mild conditions, low cost, and good yield stability in scale-up reactions, broadening the methodology for the late-stage modification of drugs and natural products.
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