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Updated: Feb 7, 2026
11:39
Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution
Published on: September 21, 2012
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Mucinous Syringometaplasia: Practical Insights from a New Case
Ana María Montaña-Ramírez1, Carmen Alfonso-Rosa, Jesús Machuca-Aguado
1Department of Pathology, Virgen Macarena University Hospital, Seville, Spain .
The American Journal of Dermatopathology
|February 5, 2026
Summary
Mucinous syringometaplasia, a rare skin condition, can mimic cancer. This study highlights its reactive nature and the importance of accurate diagnosis using morphology and specific stains to prevent misdiagnosis.
Area of Science:
- Dermatopathology
- Oncologic Pathology
- Histopathology
Background:
- Mucinous syringometaplasia is a rare adnexal process.
- It can be misdiagnosed as mucinous carcinoma or metastatic mucinous adenocarcinoma.
- Diagnostic challenges arise from its potential to mimic malignancies.
Purpose of the Study:
- To present an additional case of mucinous syringometaplasia.
- To emphasize diagnostic considerations and pitfalls.
- To discuss its likely reactive/metaplastic nature.
Main Methods:
- Histopathological examination of a skin lesion.
- Analysis of epidermal invagination connected to eccrine ducts.
- Use of Alcian blue stain and CDX2 immunohistochemistry.
Main Results:
- Histology showed eccrine duct metaplasia with goblet cells.
- The lesion was strongly Alcian blue positive and CDX2 negative.
- Findings supported a primary cutaneous eccrine-derived mucinous metaplasia.
Conclusions:
- Mucinous syringometaplasia is likely a reactive/metaplastic process.
- Accurate diagnosis requires correlating morphology with mucin stains and immunohistochemistry.
- Standardized criteria and registries are needed to improve understanding and avoid overdiagnosis.
Keywords:
cutaneous mucin depositioneccrine duct metaplasiagoblet cell metaplasiamucinous syringometaplasiaMore Related Videos
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