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Updated: Feb 7, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Photodriven Enantioselective 6-endo Hydroaminative Cyclization to Chiral 4-Substituted 3,4-Dihydroisoquinolones
Jiahao Zhang1, Chaoren Shen1, Zheng Huang2,3
1State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Abstract:
A photocatalytic asymmetric protocol for the synthesis of chiral dihydroisoquinolone scaffolds, which are prevalent in natural products and pharmaceuticals, has been developed. Utilizing chiral C2-symmetric arylthiol as an H atom transfer catalyst, the enantioselective hydroamination-cyclization provides efficient access to a wide range of valuable 4-substituted 3,4-dihydroisoquinolones with moderate to high regio- and enantioselectivity. The synthetic utility of this methodology is demonstrated by the formal synthesis of several bioactive alkaloid intermediates.
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