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Updated: Feb 7, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Iron-Catalyzed Photoredox Decarboxylative Hydroalkylation with Alkynes and Alkenes
Zhenzhu Hu1, Haoran Yuan1, Yuxin Lin1
1College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian, Henan 463000, P. R. China.
Abstract:
A photocatalyzed decarboxylative hydroalkylation approach has been developed, providing efficient and stereoselective access to synthetically challenging Z-configured allylamine derivatives from carboxylic acids and alkynes. The reaction is mediated by an iron catalyst, offering a green, environmentally benign, and highly atom-economical process. Moreover, this protocol can be extended to the reaction with alkenes to furnish arylamines and aryl ethers. Overall, this strategy establishes a versatile synthetic platform for the functionalization of unsaturated hydrocarbons.
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