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Updated: Feb 7, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Fertility Preservation in Female Cancer Patients: Comprehensive Clinical, Surgical, and Radiologic Guide for

Martina Aineseder1, Sara Hassanzadeh2, Mariano Lorea1

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Summary
This summary is machine-generated.

Fertility preservation options like fertility-sparing treatment (FST) and fertility-preserving treatment (FPT) are vital for young women with gynecologic cancers. Imaging and pathology guide personalized FST and FPT protocols, balancing cancer control with reproductive future.

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Area of Science:

  • Gynecologic Oncology
  • Reproductive Medicine
  • Medical Imaging

Background:

  • Fertility preservation is crucial for young women diagnosed with gynecologic malignancies.
  • Available options include fertility-sparing treatment (FST) and fertility-preserving treatment (FPT) like cryopreservation and surgical transposition.
  • These treatments aim to balance oncologic safety with future reproductive choices.

Purpose of the Study:

  • To review fertility-sparing treatment (FST) and fertility-preserving treatment (FPT) options for young women with gynecologic cancers.
  • To highlight the role of MRI in assessing tumor extent for FST suitability.
  • To emphasize a comprehensive approach for personalized fertility preservation strategies.

Main Methods:

  • Review of FST and FPT modalities for endometrial, cervical, and ovarian cancers.
  • Discussion of MRI's role in evaluating tumor characteristics and extent.
  • Integration of imaging, histopathology, and patient counseling for treatment planning.

Main Results:

  • FST protocols vary by cancer type: endometrial (hysteroscopic resection/D&C + progestin), cervical (conization/trachelectomy + lymph node assessment), and ovarian (select cases like borderline or early-stage epithelial/germ cell/sex cord stromal tumors).
  • MRI is pivotal for assessing tumor invasion and extent, crucial for FST eligibility.
  • FST in ovarian cancer is associated with high survival rates (>90% in early stages), though recurrence risk varies.

Conclusions:

  • A multidisciplinary approach combining imaging (especially MRI), histopathology, and patient counseling is essential for personalized FST and FPT.
  • This integrated strategy ensures oncologic safety while respecting patient autonomy in reproductive decision-making.
  • Tailored fertility preservation plans are key for young women undergoing cancer treatment.