Related Experiment Video
Updated: Feb 7, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Prognostic value of the baseline triglyceride-glucose-body mass index in small cell lung cancer undergoing
Dongyong Zhu1, Yusheng Guo1, Weiwei Liu1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1277, Wuhan, 430022, China; Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan, 430022, China; Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Background:
The prognostic role of the triglyceride-glucose-body mass index (TyG-BMI), a surrogate marker for insulin resistance, in small cell lung cancer (SCLC) patients treated with immune checkpoint inhibitors remains undefined.
Methods:
In this multicenter retrospective study, SCLC patients who initiated first-line chemoimmunotherapy or chemotherapy alone between March 2015 and December 2023 were enrolled. The association between baseline TyG-BMI index and survival was analyzed using Kaplan-Meier and Cox regression methods. A prognostic nomogram was developed and validated via time-dependent ROC and calibration analyses.
Results:
Among 437 patients, a low TyG-BMI index was significantly associated with improved overall survival (OS) in the chemoimmunotherapy cohort (P < 0.001). In the chemotherapy-alone cohort, a high index predicted worse progression-free survival (PFS, P = 0.031). The TyG-BMI index was an independent prognostic factor for both PFS (HR = 1.44, P = 0.005) and OS (HR = 1.42, P = 0.002). The nomogram demonstrated good predictive accuracy for OS (9-18 month AUCs: 0.72-0.73; C-index=0.66, 95 % CI: 0.63-0.69) and was well-calibrated.
Conclusion:
The baseline TyG-BMI index is a treatment-specific prognostic biomarker. A low index identifies SCLC patients most likely to achieve long-term survival benefit from chemoimmunotherapy, offering a practical tool for risk stratification and therapeutic guidance.
More Related Videos
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
09:45Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Related Concept Videos
Reduced Mass Coordinates: Isolated Two-body Problem
Lung Capacity
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Neurons: The Cell Body and the Dendrites
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...