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Updated: Feb 7, 2026

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
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Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

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Bioengineered chimeric VLPs targeting chikungunya virus and SARS-CoV-2 show high immunogenicity in mice

Vedita Anand Singh1, Sanketkumar Nehul1, Ankita Saha1

  • 1Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.

Biochemical and Biophysical Research Communications
|February 5, 2026
PubMed
Summary

This study introduces Chimeric Alphavirus-Coronavirus Virus-Like Particles (ChAC-VLPs), a novel bivalent vaccine targeting Chikungunya virus (CHIKV) and SARS-CoV-2. ChAC-VLPs demonstrate significant neutralization capabilities against both viruses in preclinical models.

Keywords:
Chikungunya virus (CHIKV)Chimeric virus-like particles (Chi-VLPs)Envelope glycoproteinNeutralizing antibody responseReceptor binding domain (RBD)Recombinant vaccine technologySARS-CoV-2

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