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Hematological inflammatory indices and their relationship to the risk of hypertension

Ju Young Jung1, Chang-Mo Oh2, Jae-Hong Ryoo3

  • 1Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Epidemiology and Health
|February 5, 2026
PubMed

Insights

Elevated hematological inflammatory indices, including the systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI), are linked to a higher risk of developing hypertension. This association holds true even in younger, healthier individuals, highlighting inflammation

Area of Science:

  • Cardiovascular Disease Epidemiology
  • Inflammation and Immunology

Background:

  • Chronic inflammation is a known risk factor for hypertension.
  • Limited data exists on the association between hematological inflammatory indices and long-term hypertension risk.

Purpose of the Study:

  • To investigate the relationship between various hematological inflammatory indices and the risk of incident hypertension.
  • To assess the predictive value of indices like NLR, MLR, PLR, SII, and SIRI for hypertension development.

Main Methods:

  • Analysis of a large Korean cohort (n=128,241) with a median follow-up of 6.8 years.
  • Utilized Cox proportional hazards models to evaluate hypertension risk across quartiles of inflammatory indices.
  • Included high-sensitivity C-reactive protein (hsCRP) and sex-stratified analyses.

Main Results:

  • 18,686 participants developed hypertension during follow-up.
  • Higher quartiles of SII, SIRI, and NLR were significantly associated with increased hypertension risk in both sexes.
  • PLR showed a stronger association in women; MLR had marginal associations, consistent with hsCRP patterns.

Conclusions:

  • Elevated hematological inflammatory indices are associated with an increased risk of incident hypertension.
  • These inflammatory markers may serve as early indicators of hypertension risk, even in younger, healthy populations.
  • Findings underscore the role of systemic inflammation in hypertension pathogenesis.
Abstract

Keywords:
Blood cellsHypertensionInflammation

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