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Three new sesquiterpenes from the secondary rhizomes of Curcuma wenyujin
Yuxin Kan1, Lijia Chen2, Shuyu Song1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Abstract:
Three previously undescribed sesquiterpenes, including one germacrane-type (1) and two guaiane-type (2 and 3), along with eighteen known sesquiterpenes (4-21), were isolated from the secondary rhizomes of Curcuma wenyujin. The structures of 1-3 were elucidated through comprehensive spectroscopic analysis, which integrated 1D/2D-NMR spectroscopic, high-resolution mass spectrometry (HRMS), electronic circular dichroism (ECD) spectra, and single-crystal X-ray diffraction (SC-XRD), together with DFT NMR calculations. Compounds 1-3 were evaluated for inhibitory effects on lipid accumulation in palmitic acid and oleic acid (PA/OA)-induced AML12 hepatocytes, and 3 exhibited a moderate inhibitory effect.
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