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Genetically predicted associations between blood cell perturbation responses and bronchiectasis through immune
Jiahui Han1, Yibo Yan2, Zhongye Du1
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Respiratory Medicine
|February 5, 2026
Summary
This study reveals immune cells partially mediate the link between blood cell changes and bronchiectasis. Findings offer new genetic insights into disease causes and potential treatments.
Area of Science:
- Genetics
- Immunology
- Pulmonology
Background:
- Bronchiectasis is a complex chronic airway disease with unclear causes.
- Previous research hinted at blood cell involvement, but causal links and immune mechanisms were unknown.
Purpose of the Study:
- To investigate genetically predicted associations between blood cell perturbation responses, immune cell traits, and bronchiectasis.
- To explore potential immune cell-mediated pathways in bronchiectasis pathogenesis.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) with genome-wide association study data.
- Employed mediation MR analyses to assess immune cell mediation.
- Conducted sensitivity analyses to ensure robustness.
Main Results:
- Identified significant genetically predicted associations between five blood cell perturbation phenotypes, 29 immune cell traits, and bronchiectasis.
- Demonstrated partial mediation by natural killer (NK) cells, transitional B cells (CD38+), and NK cells (CD45+) in specific pathways.
- Quantified mediation proportions for identified immune-mediated effects.
Conclusions:
- Provides novel genetic insights into bronchiectasis pathogenesis through immune-mediated pathways.
- Highlights potential therapeutic targets for future bronchiectasis treatment strategies.
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