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Updated: Feb 7, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Atrial fibrillation and heart failure with preserved ejection fraction: diagnostic challenges and therapeutic
Faro Verelst1,2, Klaus K Witte3, Fozia Z Ahmed4
1Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium.
Abstract:
Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterised by cardiac and non-cardiac physiologic disturbances, commonly underpinned by cardiometabolic abnormalities, which culminate in elevated left ventricular filling pressures and progressive symptoms of exercise intolerance. Arrhythmias, particularly atrial fibrillation (AF), are common in HFpEF and have important clinical implications. AF complicates the diagnosis and management of HFpEF. In this review, we synthesise the impact of AF on disease detection, symptom burden and prognosis and HFpEF treatment. Furthermore, we review pharmacological and interventional therapies that may mitigate the risk of AF and improve how patients with HFpEF feel, function and survive.
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